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Antacids, glucosamine, laxatives, aminoglycosides slow down and reduce absorption; ascorbic acid increases absorption.
Bacteriostatic antibiotics (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) have an antagonistic effect.
Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index). With the simultaneous administration of anticoagulants, it is necessary to monitor blood coagulation.
Reduces the effectiveness of oral contraceptives, drugs, during the metabolism of which PABA is formed, ethinyl estradiol - the risk of bleeding “breakthrough”.
Diuretics, allopurinol, phenylbutazone, NSAIDs and other drugs that block tubular secretion increase the concentration of amoxicillin (clavulanic acid is excreted mainly by glomerular filtration).
Allopurinol Increases Risk of Skin Rash.
A description of the active substances of the drug is provided. The scientific information provided is generalized and cannot be used to decide on the possibility of using a specific drug.
Healing properties
The active substance of Augmentin is represented by amoxicillin, which is a semi-synthetic antibiotic with a wide range of effects. High activity of the drug can be observed in relation to a number of harmonic (streptococci, Staphylococcus aureus, pneumococci) and gram-negative pathogenic flora (pertussis, cholera vibrio, gardnerella). Amoxicillin does not have a detrimental effect on microorganisms producing beta-lactamase, since under their influence there is a destruction of the antibiotic.
The second active ingredient, namely clavulanic acid, is represented by a compound of beta-lactams, which can have a stopping effect on beta-lactamase and other enzymes that are resistant to penicillin group antibiotics and cephalosporins.
Thus, clavulanic acid is a kind of protective shield of amoxicillin from the harmful effects of beta-lactamases, due to this the bacterial properties of Augmentin expand.
Using oral Augmentin tablets or buy amoxicillin clavulanic acid, there is a rapid absorption of the active substances by the gastrointestinal mucosa. Optimum absorption rate can be achieved by taking tablets before meals..
With oral administration and intravenous injection, the main components of the drug penetrate into the tissues, as well as interstitial fluids.
The relationship of the active substances of Augmentin with albumin is minimal.
During active metabolization, the release of metabolites occurs by the kidneys, gastrointestinal tract, and also the respiratory system in the form of a carbon compound.
At what age is allowed to take
This drug can be given to children from birth, but the doctor can determine the exact dosage, and such treatment is carried out only in a hospital. http://www.goodrx.com/augmentin/side-effects In this case, the risk and benefit of using such an antibiotic for a small organism are necessarily taken into account and analyzed..